Italian police on Tuesday arrested 28 people in a probe into the penetration of the Camorra's Senese clan into Rome's economic and business fabric.
Dawn raids were carried out in the provinces of Rome, Naples, Verona, Frosinone, and L'Aquila.
Over 200 police and finance guards took part in the operation.
Those arrested were accused of extortion, usury, fraudulent transfer of goods and assets, money laundering, and reusing ill-gotten gains.
Assets worth some 15 million euros were seized.
Police said they had "decapitated" the leadership of the Senese clan operating in the Italian capital.
They said the Camorra clan had been operating in Rome for many years.
Among those issued warrants were clan leader Michele Senese aka "O' pazz" (Crazy), currenty in jail for a 2001 murder; his brother Angelo Senese; his son Vincenzo; and his wife Raffaella Gaglione.
They are all accused of using mafia methods to help the Campanian mafia penetrate the Roman economy.
The Camorra is based in Campania, the region around Naples, but also operates elsewhere in Italy and abroad. (ANSA).