Falcone estimated that the Gambinos and the Inzerillos made 600 miliond a years and in the Iron Tower ring they was selling pure heroin to 200K a kilos and an informer said that a mobster had 1000 kilos hidden in NY. I thik that was the last profitable drug ring that involved NY families.
In the 1990s there was also Project Omerta, which dealt a severe blow to the Cuntrera-Caruana organization, who's buyers in NY were the Gambinos and Bonannos.