https://www.nytimes.com/1988/12/02/us/dozens-are-seized-in-new-us-italian-drug-sweep.html

Falcone estimated that the Gambinos and the Inzerillos made 600 miliond a years and in the Iron Tower ring they was selling pure heroin to 200K a kilos and an informer said that a mobster had 1000 kilos hidden in NY.
I thik that was the last profitable drug ring that involved NY families.