The Greco Mafia family (Italian pronunciation: [ˈɡrɛːko]) is a historic and one of the most influential Mafia clans in Sicily and Calabria, from the late 19th century. The extended family ruled both in Ciaculli and Croceverde Giardini, two south-eastern outskirts of Palermo in the citrus growing area and also rural areas of Calabria where they controlled the olive oil market.

The Greco clan lost its grip on the mandamento of Ciaculli, which was merged with Brancaccio and the leadership eventually was passed on, but its criminal presence emerged into Calabria in the late 1990s and with the turn of the new millennium, Interpol and FBI intel information showed that the reemergence of the Greco Clan was strongly evident in the United States and Australia, the Grecos were no longer part of the power structures of Cosa Nostra but restructured their organization to adapt to the new ways of organized crime.