Detroit should be tier 1 in the pre-Rico days. Hoffa according to rules belonged to Detroit, even though he clearly had liaisons in other places. We're talking the Teamsters nationwide, who were involved with the development of almost everything then.
Buffalo should be tier one just for the fact that Maggadino was on the original commission.
Trafficante and Marcello, with their connections to Costello and Lansky should be tier 2. Trafficante is arguably tier 1 in the 50s. Solidly connected to NY and was the primary liaison to pre Castro Cuba and the casinos.
Bufalino probably tier 2, same reasons as Detroit. Hoffa.
Tier 4 seems low for KC, Pittsburgh and Cleveland in the 50's and 60s. KC was powerful through teamsters, Vegas connections as late as the 80s.