As far as on a nationwide level , I'd say the Sinaloa and Jalisco New Generation Cartels . After all they operate in various parts of the country as opposed to select areas , control a very large chunk of the drug market , and have great influence over the actions of other criminal organizations .
What influence do they have over other crime groups in the US?
If you think you are too small to make a difference, you haven't spend the night with a mosquito. - African Proverb