i dont see any older guys or even guys in their 40s moving anywhere, leaving their families or even moving them unless their dead certain its going to be worth it. Also does anyone think any of the bosses are gonna send them help or backup if they run into trouble in their new homes?

Having said that drugs would be the easiest thing to expand with into other areas. New York is one of the biggest drug markets and hubs in the USA, they do have access to the best quality coke,heroin. They can go and sell drugs from new york and the money would be good but it also comes down to the muscle and protection of their operation, if they are not able to provide this then its just not worth the risk.
The only groups i have seen do this are ny street gangs.
Miller time bloods,NY-virginia
old bronx gang pops up in vermont

I also think it would depend on the quantity of drugs they would be selling, any major weight would attract competition.