I always liked Ralph, lol. He was a prick but the guy was real funny and a tremendous earner. How can you hate Artie?

My vote is split between AJ and Janice. AJ is a spoiled ungrateful little shit with serious attitude problems. The greatest scene ever was when Tony told AJ that Baccala is dead and AJ starts crying and Tony drags him out of bed and on the floor with AJ's nintendo cable around his legs. That was class.

Janice was a manipulative c*nt with no work ethic whatsoever. She lived off manipulating those around her to get her ways. Everything about her is annoying: Her taste of music, her hippie looks, the constant nagging and complaining, and finally her own inability to stay in a stable relationship without fucking it up.
She didn't exactly pick the right boyfriends either too (if you exclude Baccala). Ralph and Richie? Come on! Fuck her fake disabilities, too. Most annoying character ever.