Up All Night star Christina Applegate is leaving the NBC comedy she helped to launch.

“It’s been a great experience working on Up All Night, but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors,” Applegate said in a statement provided to EW. “Working with Lorne Michaels has been a dream come true and I am grateful he brought me into his TV family. I will miss the cast, producers and crew, and wish them the best always.”