It's probably not going to be a major factor in 2012.

JFK's religion was a factor in the 1960 election. After that, few Americans knew, or cared, that Barry Goldwater's running mate in '64, Congressman Bill Miller from upstate NY, was Catholic.

Nelson Rockefeller divorced his wife of 30+ years and remarried to a woman 18 years his junior, who left her husband and kids for him, not long before he ran for the GOP nomination in '64. The divorce hurt him. But Ronald Reagan swept the GOP nomination, and the presidential race in 1980, on a family-friendly platform despite having divorced his first wife years earlier, and being estranged from one of his children.

Geri Ferraro raised a lot of eyebrows when she became the Dem VP nominee in '84. Not many blinked in '08 when Sarah Palin got the GOP VP nod.