I believe, we need it. We are matured and grown enough for it.
The movies dialogue games soon begin to repeat themselves. This one has a much wider potential.
Since it is a novel, if the quote is not very individualized, make it longer, so we could recognize it. Two - three word quotes are not encouraged.
If the quote is not from direct speech, the one who answers must say from which part of the story it is and what it is about. If it is - who says it to (or about) whom and in which part of the story (If it isn't obvious, of course).
Choose quotes mercifully, games exist to give pleasure!

I'll start with an easy one:

"Hey, kid, they won't give you medals, they put you in the electric chair."