I believe that the firt use of the RICO act was against a mobster named Frank "Funzi" Tieri back in the early 80's.

And if I'm not mistake, former U.S. Attorney Rudy Giuliani was one of the first to use the RICO act against a non mobbed up businessman who was a junk bond trader and schemer named Michael Milkin. He was charged with Racketeering and fraud. First Ivan Boesky, a Wall Street mogual, was arrested for insider trading. He turned state's evidence and ratted on several of his cohorts including Michael Milkin. And the RICO act was used in prosecuting all those who Boesky ratted on.

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Five - ten years from now, they're gonna wish there was American Cosa Nostra. Five - ten years from now, they're gonna miss John Gotti.