The end of Godfather III, when Mary is killed and Michael screams in agony.

That scene itself should have one a couple oscars. Unbelievable. You can't help but tear up for thet scene, because (if you have scene the two movies before) you know how much he's struggled to keep his family safe. Especially, within the first 45 minutes of the third film, he states "I would burn in hell to keep you safe", directly to Mary. And then, when she dies, he notices he's lost. He's lost his first wife, Appolonia, and Kay, his second wife and finally his daughter, Mary. He lost the three women, the only women, he really ever loved. That scream was unbelievable. Also, the memory of those three women that he's ever loved are brought back to us immediately after the scream showing us that he failed all of them.

I replay that scream all the time and always tear up. Amazing scene.