The CIA wasn't involved in either murder, stop. Nobody at a national security level cared that much about either of them. One person who surely was involved in Tupac's was not only Suge Knight from the standpoint of negligence, but Sean Combs. Knight owed more than 104 Million to Death Row artists at the time of Tupac's death, much of it to him. Tupac had threatened on a handful of occasions to not only leave Death Row but to take his catalogue with him, which would've been a major blow to Knight. Knight's wife ran ALL of the security for Death Row with her boyfriend, which allowed on the night of the murder to have very little security in the surrounding cars. All Death Row security was advised on the night of the murder to leave guns at their hotel rooms, and not in vehicles or to be armed at the 622 Club - the club owned by Suge to which they were on their way to. This is corroborated by Frank Alexander, Tupac's primary bodyguard who refused. It also should be noted that Suge Knight himself rarely drove, yet decided to drive on the night of the murder.

Combs had a well known 1 Million Dollar Bounty on Tupac (and Suge). It was basically prime opportunity for Orlando Anderson and Keefe D both well aware of the bounty to attempt to cash in on it. LAPD, while on staff with Knight's wife, was probably not involved in his murder - but VERY much involved in Biggie's murder.