yes, some bosses have been able to get around 41 bis and still run their clans but the vast majority remain isolated in fact dismantling the 41bis regime was among Riina's requests to the government in the early 1990s.
Recently a 100-day hunger strike by an anarchist leader (Alfredo Cospito) has reignited debate in Italy over the use of Western Europe’s harshest prison regime for dangerous offenders.


Alfredo Cospito: Hunger-striking Italian anarchist moved amid protests

https://www.bbc.com/news/world-europe-64467764