Does anyone remember a restaurant in Harlem called Tre Amici around the middle to late 70's?

Tri Amici Ristorante was not located in Harlem, but rather on the Upper East Side of Manhattan around 70th to 85th Streets I'd say (somewhere around there). This particular eatery had excellent food. A mix of northern and southern Italian. The joint was connected to several guys in the Genovese Family who had hidden interests there.

Man ,,,,these restaurants changed names so quick we would go there one month and the next everything was the same other than the name.
Same guys , same food, same everything other than the sign.

One of the very best old-time Southern Italian restaurants was Downtown NY, Grand St., in Little Italy. It was called Ruggero. It was diagonally across the street from the famous Ferrara's Pastry Shop. Another nice place with great food, more casual, was Angelo's on Mulberry Street. It was there since the days of Lucky and Vito.

A top place on the Upper East Side, Northern Italian cuisine, was called "Nanni au Valetto"....

They're both long gone now, but decades back they were among our favorites. I think Angelo's may still be there (but its not the same kinda neighborhood anymore)

The Pork store on the corner there closed, that place was there for ever.

Alleva

Yeah, I heard that. As you say, they were a staple in the neighborhood forever. Its a shame how some things change. But thats what life is, I guess. Aside from the string of restaurants that still dot Mulberry Street (many of which are relatively new themselves, and now cater to the tourists, rather than to native New Yorkers), the neighborhood is almost unrecognizable from years back.

Little Italy is getting littler by the day!