For the Colombo's between 2000 and 2008 were terrible years as they had a LOT of defectors four captains:

1) Paul Bevalaqua
2) Dino Calabro
3) Raynald Marangi
4) Anthony Russo

Big hit and they whacked Wild.Bill

And at least as many made men flipped as well.

Since then the feds have not really hurt them at all.