I have to disagree with this strongly, though I understand that you express a personal opinion regarding your own viewing experience. I agree with your example of "Lost in translation" which I regard as an excellent movie.
I don't mind if a film leaves the audience to form their own interpretation. For example "Broken Flowers". It is an excellent movie, shows the character from a distance, has a small mysterious element in the form of a pink letter, but at the same time is a straight narrative. But my complaint with Mulholland Drive is not about mystery or interpretation, but about mixing up real and fantasy plots conveniently in order to create a mystery out of nothing.