I think a tv show about all of the five families from 1945 until 1963 would be absolutely epic. I don't know how it would all be brought together but just think about all of the things that happened during that period.
1945 Vito Genovese sent back to US from Italy faces murder charges (2 witnesses killed)
1946 Lucky Luciano freed from prison but deported
1946 Havanna Conference
1947 Bugsy Siegel killed
1951 Mangano brothers killed
1951 Gagliano retires Lucchese becomes boss
1951 Willie Moretti killed
1952 Frank Costello Kefauver Hearings testimony
1952 Arnold Shuster killed on orders of Albert Anastasia
1957 Frank Costello murder attempt
1957 Frank Scalise killed
1957 Albert Anastasia killed
1957 Grand Hotel des palmes mafia summit Joe Bonanno in attendance
1957 Apalachin Meeting
1959 Vito Genovese sent to prison
1959 Anthony Carfano and Janice Drake Killed
1962 Lucky Luciano and Joe Profaci dies
1962 Anthony 'Tony Bender' Strollo killed
1963 Profaci-Gallo War
1963 Valachi testimony
There would be lots of storylines in that show for sure.