It would be similar as with the rest of society. A Republican would be better for the wealthy bosses that have money tied up in big business, Wall Street, etc. A Democrat would be better for the working class heavy lifters. Less jail time, more union jobs available as fronts, etc.

"...the successful annihilation of organized crime's subculture in America would rock the 'legitimate' world's foundation, which would ultimately force fundamental social changes and redistributions of wealth and power in this country. Meyer Lansky's dream was to bond the two worlds together so that one could not survive without the other." - Dan E. Moldea