If the thread is about the pinicle of OC in North America then it is indisputable that it is the drug cartels who by any definition are the most powerful.

A cartel (insert your choice here) would wipe the floor with even the Genovese.

But all operate in separate spheres with minimal overlap.

CN doesn't sling crack on corners, Los Zetas isn't big into loan or gambling.
Each has their niche.
But dollar wise the cartels shit on CN.
Hell if you take the bloods and the crips as nation wide syndicates, they do too.