Maybe not. But they've survived worse things in their past than what Nicodemo could possibly do if he flipped or what would happen once the Feds possibly/eventually dismantle Merlino and his hierarchy at the top.

Whether Scarfo was a homicidal maniac or a bad boss is a different debate, but what happened during his reign and then the war that continued with Stanfa afterwards seriously crippled the family, but never decimated it.

In 30 years, people will still be gambling, buying/selling drugs, and other vices that are primary staples of the mob. Just like the rest of the remaining families today (and all organized crime in general), I'm sure they can be critically wounded but I don't know if they can ever fully be finished off.