BarrettM, it is hard to trace these mafia groups origins as there were more than Just the five families operating in New York before the formations of the families.

You can trace the Profaci crime family to Joe Fontana who was killed in 1913 in Harlem. From 1913-1925, Salvatore DiBella was the boss. From 1925-1928, a Zarcone was the boss. Then Joe Profaci took over.

As for Joe Profaci being involved with drugs, there is some hints that before he moved back to Brooklyn from Chicago, that he did do some minor transactions while as a grocer to make the move. After he moved back to New York, it seems he had no more dealings with drugs personally, but members in his crime family were heavy in it. No doubt, Profaci made sure he got his cut.