From what I can tell, the Detroit crime family had large amounts of the materials used to make narcs, and many other crime families did business with them, till the U.S. Sicilian pipeline was put in place.
also, I understand that before the Italians too over the heroin trade, the Jews controlled it, and that the street name for heroin "smack" is derived from the yiddish "schmeck" = a sniff, a whiff, a taste with violent effect. and "schmecker" = heroin user
this is why angelo tuminaro (uncle of patsy fuca of "french connection" fame) was such a key player, as he was married to the daughter of a prominent jewish gangster.