Being as Vito Genovese was at the center of it, it certainly looks like it concerned drugs, didn't it.

A law was passed the prior year, the Narcotic Control Act of 1956.

Here is a partial synopsis of it...

" Narcotic Control Act

Jennifer M. Cameron & Ronna J. Dillinger

The Narcotic Control Act was passed in 1956 in response to the results of a nationwide investigation of narcotics trafficking, addiction, and treatment. The act imposed some of the strictest drug control penalties to date, and was supported by the Federal Bureau of Narcotics (FBN) as a means of reducing narcotics trafficking and use in the United States. The act increased the penalties and mandatory minimum prison sentences outlined by the Boggs Act of 1951 and introduced the death penalty for certain drug offenses. The mandatory minimum sentences imposed by the act were later eliminated by the Comprehensive Drug Abuse Prevention and Control Act of 1970. The Boggs Act established strict criminal penalties (including mandatory minimum prison sentences) for those who violated the existing laws related to narcotics trafficking and use. Shortly after the Boggs Act passed, Harry Anslinger of the FBN reported a sharp decline in narcotic use by ... "

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Therefore, whether Anastasia was hit or not, whether Vito Genovese would have assumed power or not, an Appalachin would have probably gone down anyway...to discuss ways to circumnavigate the new draconian anti drug laws.