I think in a sense we are comparing apples to oranges. Denaro is diversified in his criminal interests while Guzman is strictly into narcotics trafficking.
i think that its a misconception to think that the cartels are strictly into narcotics. while that is without question thier #1 moneymaker by far, people dont realize that they are very much into human trafficing/prostitution as well as shakedown/protection rackets in mexico as well as america. im not saying they are nearly as diversified as the mafia but they are far from the one trick pony they are so often portrayed as.