Without a doubt, the real godfather of Vegas is Moe Dalitz. He also serves as the model for how to be "legitimate" in Nevada through political contributions, charities, civic works, etc. No project on Vegas would be complete without mentioning Bugsy Siegel, but you will find that his actual role in the growth of Vegas has been somewhat exaggerated.
Among Mafia families: look first for Frank Costello, then Chicago, then Detroit, and then Kansas City.