Your point's well taken. As long as people want to indulge in illegal activities--patronize prostitutes, use drugs, buy merchandise that "fell off the back of a truck," gamble, take loans they don't qualify for--there'll always be criminal organizations to satisfy their needs.
You might also argue that RICO in general, and the Commission case in particular--dealt the Mafia a crippling body blow, amd further fragmented the families. But one difference twixt the Mafia and the Rangers, Crips, and other street-based gangs is that the Mafia at one time enjoyed tremendous political clout--and the street gangs didn't.