House usually comes on Tuesday's at 8 or 9, on FOX. Season 4 starts in January.
At it's most basic, House is a medical drama. But it has more in common with CSI than it does with...say, ER or Grey's Anatomy.
Dr. Gregory House is an asshole, in every sense of the word. He has a very rude bedside manner. But he's a genius. You really have to watch the show, as no description I give can do it justice.
I dunno if you're willing to drop around 40 bucks for the first season, but rest assured I wouldn't steer you wrong. It is an absolutely fantastic show, and I'm 100% certain you won't be disappointed.