As far as the children, I don't think so and agree with some of the reasons already given here as to why probably nothing will happen to them. Of course he'd be crushed if something happened to one of his kids. But I just don't think that is where these episodes will go.

However, I think that if something were to happen to Carmela, it would destroy Tony because of how he's basically treated her like shit over the years. He's cheated on her and decieved her about many things. Then when the chips were down and he was facing death, she stood by him, pledged her loyalty to him and took care of him like a loving wife, despite all his infidelities. And he knows that. This is why I get the feeling that something is going to happen to her. If something does, his guilt will destroy him.

In a Daily News interveiw with Lorraine Bracco, she says that we will be shown an ending that we could never even imagine.