The best time, MC, is anytime before 2 AM (Central) early Sunday morning. I wouldn't cut it that close though with the whole Spring Forward- Daylight Savings Time thing. That's this weekend, right?

Once the season really gets going, I imagine I'd do the same as I did last year - I would do my lineups at the beginning of the day, tinker with it throughout the day, and check it one last time before going to sleep.