Originally posted by Antoni Canoli:
So... can I fiddle around doing my own thing (such as extortion, taking over compounds/wherehouses, and doing hits) and ignore the story mission without being harmed (by that I mean damaging the story and my standing in the family)??
Oh definitely. My first time through the game, I would complete a mission, then take over 5 or 6 businesses and/or warehouses before continuing with the story. It's actually a good idea, because the more respect you gain, the more you can upgrade your stats, and the less trouble you'll have in the tougher missions later on in the game.