A criminologist narrates the tale of the newly engaged couple Brad Majors and Janet Weiss who find themselves lost and with a flat tire on a cold and rainy late November evening. Seeking a telephone, the couple walk to a nearby castle where they discover a group of strange and outlandish people who are holding an Annual Transylvanian Convention.

They are soon swept into the world of Dr. Frank N. Furter, a self-proclaimed transvestite from Transsexual, Transylvania. The ensemble of convention attendees also includes servants Riff Raff, his sister Magenta, and a groupie named Columbia.